Bioinformatics: Sequence Alignment and Markov Models

Authors: Kal Sharma
Format: Hardback

Bioinformatics showcases the latest developments in the field along with all the foundational information you'll need. It provides in-depth coverage of a wide range of autoimmune disorders and detailed analyses of suffix trees, plus late-breaking advances regarding biochips and genomes.

Featuring helpful gene-finding algorithms, Bioinformatics offers key information on sequence alignment, HMMs, HMM applications, protein secondary structure, microarray techniques, and drug discovery and development. Helpful diagrams accompany mathematical equations throughout, and exercises appear at the end of each chapter to facilitate self-evaluation.

This thorough, up-to-date resource features:

Worked-out problems illustrating concepts and models
End-of-chapter exercises for self-evaluation
Material based on student feedback
Illustrations that clarify difficult math problems
A list of bioinformatics-related websites

Bioinformatics covers:

Sequence representation and alignment
Hidden Markov models
Applications of HMMs
Gene finding
Protein secondary structure prediction
Microarray techniques
Drug discovery and development
Internet resources and public domain databases

Table of contents

Preface
Acknowledgments
Chapter 1. Preliminaries
Part 1: Sequence Alignment and Representation
Chapter 2. Alignment of a Pair of Sequences
Chapter 3. Sequence Representation and String Algorithms
Chapter 4. Multiple-Sequence Alignment
Part 2: Probability Models
Chapter 5. Hidden Markov Models and Applications
Chapter 6. Gene Finding, Protein Secondary Structure
Part 3: Measurement Techniques
Chapter 7. Biochips
Chapter 8. Electrophoretic Techniques and Finite Speed of Diffusion
Appendix A. Internet Hotlinks to Public-Domain Databases
Appendix B. PERL for Bioinformaticists
Index

Author comments

Kal Renganathan Sharma, Ph.D., P.E., has written five books, 11 journal articles, and hundreds of conference papers. He has held a number of high-level positions at engineering colleges and universities. Dr. Sharma currently teaches at Prairie View A&M University in Prairie View, Texas.